Takemura et al. [26] showed that BNP levels were higher in patients with cardiac amyloidosis than in control patients and they showed by immunohistochemistry of the myocardium that BNP expression in patients with cardiac amyloidosis was greater in the endocardial side than in the epicardial side and in myocytes neighboring deposited amyloid. This evidence concerns the gene NPPB and amyloidosis.