Of note, IL-6, together with other pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNFa) and Interleukin-1 (IL-1), can inhibit triglyceride synthesis and, at the same time, can promote insulin resistance in various target tissue, highlighting the complex interplay between metabolic and biochemical inflammatory pathways in CV [19]. Here, TNF is linked to Insulin resistance.