These data indicate that the lnc021545-miR-330-3p axis mediated EMT process to inhibit the metastasis of BC cells via specifically suppressing EREG expression, and it verified that the effect of the lnc021545-miR-330-3p axis in repressing the metastasis of BC primarily depends on the EREG to influence the changes of EMT markers. The gene discussed is EREG; the disease is breast cancer.