In 50 BC patients, we observed that miR-330-3p expression was elevated in cancerous tissues and related to tumor size, TNM stage, lymph node metastasis, pathological stage, and HER-2 amplification while lnc021545 and EREG were decreased in BC tissues and exerted the opposite effects of miR-330-3p in the BC patient cohorts. The gene discussed is EREG; the disease is breast cancer.