Furthermore, in experimental studies on mouse models, it was observed that in mice with imiquimod-induced psoriasis-like dermatitis and in atopic dermatitis Japanese mice, the administration of a MOR antagonist and a KOR agonist leads to the reduction of scratching, which additionally confirms the role of opioids in the sensation of itching in inflammatory dermatoses [51,52]. Here, OPRK1 is linked to atopic eczema.