To date, several biomarkers, such as fibrinogen, red cell distribution width, mean platelet volume, interleukins, CRP, procalcitonin, 5-hydroxyindoleacetic acid, hyponatremia or hyperbilirubinemia, have been investigated for acute appendicitis with varying diagnostic accuracy in published studies [1,21,22,46]. The gene discussed is CRP; the disease is appendicitis.