In a large prospective observational study [PANTS (personalized anti-TNF therapy in Crohn’s disease (CD))], which included 1610 patients under both IFX and ADA treatment, low week (w) 14 TCs were independently associated with primary treatment failure (w14), and were highly predictive of w54 non-remission and immunogenicity [18]. Here, TNF is linked to Crohn disease.