Furthermore, it can combat the negative effects of corticosteroids in the body, as Lee et al. [44] observed that mice injected with corticosterone displayed depression-like behavior; however, phenylethylamine had an antidepressant effect in corticosterone-treated mice by modulating the BDNF/TrkB/CREB signaling pathway. The gene discussed is CREB1; the disease is depressive symptom measurement.