Among the top 20 signalling pathways that were significantly enriched in KEGG in the CPC15 group compared with the FM group, seven were related to Organismal Systems, four to metabolism and six to human diseases, with the top five signalling pathways being IL-17 signalling pathway (ko04657), Toll and immune deficiency (IMD) pathways (ko04624), apoptosis (ko04210), carbohydrate digestion and absorption (ko04973), and beta-Alanine metabolism (ko00410; Figure 6A). Here, IL17A is linked to Immunodeficiency.