Though a consistent overlap exists, IgE-mediated forms usually consist of typical immediate reactions (from skin, respiratory, gastrointestinal, or cardiovascular reactions to anaphylaxis), whereas non-IgE-mediated forms can manifest as food-protein-induced enterocolitis syndrome (FPIES) or food-protein-induced proctitis/proctocolitis (FPIAP) [48]. The gene discussed is IGHE; the disease is anaphylaxis.