AR and prostate carcinoma: Reduction in steroid receptors transcriptional activity by Chios Mastiha have also been observed in LNCaP and PC-3 human prostate cancer cells, where a reduction in androgen receptor (AR) transcriptional activation, inhibition of the AR binding to AR-response elements, and a reduction in AR protein levels in a dose-depended manner by Chios Mastiha was documented [55].