It was hypothesized that because of their mucosal skin and living in water, in teleost fish the allograft rejection against potential transferable cancers should be especially important [54], and the DLA-88*0 versus DLA-88*5 differences in canines may be an example of how allelic MHC variation can also be increased in mammals, to help allograft rejection of cancers that are transferred through mucosal tissues. This evidence concerns the gene HLA-C and cancer.