They add the surprising observation that abnormal protein aggregates can already be observed at the early stages of neurodegeneration, not only in photoreceptors but also in non-photoreceptor cell types, and that they include aggregates of RBPs—most prominently of TDP-43, an important player in the pathophysiology of several major neurodegenerative diseases including ALS/FTLD [45,52]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.