Aerosol sensitization, more physiologically like naturally occurring asthma, with low-dose OVA induces EAR and LAR with IgE and IgG1 production and high-dose OVA induces EAR, airway eosinophilia, and airway hypersensitivity [90,91,92]. The gene discussed is IGHE; the disease is Increased total eosinophil count.