Several other molecules also demonstrated beneficial effects in experimental subarachnoid hemorrhage (SAH), including resveratrol, melatonin and AG490 (inhibitor of JAK/STAT3); these agents mainly inhibit HMGB1 expression and release, further ameliorating neural apoptosis and brain edema and downregulating SAH-induced inflammatory markers [87]. The gene discussed is HMGB1; the disease is subarachnoid hemorrhage.