KCNA3 and Mental deterioration: Multiple experimental interventions have shown promising results in modulating microglial activity, including minocycline [56], ketamine [57], cholinergic inhibition [58] and vagal nerve stimulation [59] as well as blocking potassium channels needed for its activation [60]; regarding the latter, pre-clinical data showed that pre-operative blocking of Kv1.3 prevented peri-operative cognitive decline, reduced hippocampal IL-6 levels and prevented microglial activation [60].