In this context, Guo et al. [15] found that TUG1 inhibits NSCLC proliferation through targeting of miR-221, it triggers growth arrest, senescence, autophagy, and apoptosis in SPC-A1 and H520 cell lines by stimulating PTEN at the G2/M phase. The gene discussed is PTEN; the disease is non-small cell lung carcinoma.