Lastly, Zhang et al. discovered a positive feedback loop leading to CRC progression where miR-17-5p was shown to be upregulated in CAFs exosomes and is secreted from CAFs to CRC cells via the RUNX3/MYC/TGF-β1 signaling pathway to promote CRC progression and metastasis [33]. This evidence concerns the gene RUNX3 and colorectal carcinoma.