Lastly, the research by Shang et al. was the first to demonstrate that CRC-derived exosomal circPACRGL, from CRC patient serum, played an oncogenic role in CRC cell proliferation, invasion and migration, and in differentiation of N1 to N2 neutrophils via the miR-142-3p/miR-506-3p-TGF-β1 axis [56]. The gene discussed is TGFB1; the disease is colorectal carcinoma.