HAT1 and liver cancer: HAT1 has been shown to bind hepatitis B core protein (HBc) via long non-coding RNAs (lncRNA) highly upregulated in liver cancer (HULC) that act as a scaffold in the complex of HAT1/HULC/HBc, which is required for viral replication of HBV cccDNA allowing chromatin assembly by histone acetylation [42].