Compared to normal cells, high levels of HAT1 protein expression were observed in several tumors, such as hepatocellular carcinoma (HCC), esophageal squamous cancer (ESC), uterine leiomyosarcoma (LMS), nasopharyngeal carcinoma (NPC), pancreatic cancer (PC), cervical cancer (CC), lip squamous cell carcinoma (LSCC), actinic cheilitis (AC), breast cancer (BC), colorectal cancer (CRC), diffuse large B-cell lymphoma (DLBCL), and peripheral T-cell lymphoma (PTCL), highlighting its potentially oncogenic role. The gene discussed is HAT1; the disease is pachyonychia congenita.