Furthermore, the HCC tumours were found to cultivate a suppressive immune system, as demonstrated by the enrichment of FoxP3+ cells (5.2% vs. 3.1%) and depletion of cytotoxic CD8+ cells (0.9% vs. 3.2%), which is in line with other studies [26,27]. This evidence concerns the gene FOXP3 and hepatocellular carcinoma.