SPARC and cataract: In the present study, we address this critical knowledge gap by performing RNA-seq analysis on newborn lenses from Celf1cKO mice and identifying cohorts of differentially expressed genes (e.g., Cryab, Cryba2, Cryba4, Crybb1, Crybb2, Cryga, Crygb, Crygc, Crygd, Cryge, Crygf, Dnase2b, Bfsp1, Gja3, Pxdn, Sparc, Tdrd7, etc.)and pathways (e.g., structural constituents of eye lens, lens development in camera-type eye, lens fiber cell differentiation, etc.)associated with lens development and cataracts.