For ‘systemic lupus erythematosus’ (449 genes in GWAS) we found 9 in our set of up-DPpGCs, namely, CLEC16A, IL18RAP, LMNTD1, PINX1, PVT1, SLC1A7, SPRED2, TET3, and a different one from the childhood onset risk locus in XKR6 [43]. This evidence concerns the gene SPRED2 and systemic lupus erythematosus.