CLEC16A and systemic lupus erythematosus: C-type lectin domain containing 16 A, CLEC16A, is an immunity-associated gene that modulates thymic epithelial cell autophagy and alters T cell selection, with its silencing in mice protecting against autoimmunity [12]; its variants are associated with susceptibility to SLE [13], and it has reduced expression in peripheral leukocytes in SLE [14].