DNASE1L3 and systemic lupus erythematosus: Although it is still under discussion how and who triggers the production of DNA antibodies in SLE, there is growing evidence that failure in the clearance of cell-free DNA (cfDNA) by deoxyribonucleases (DNASES), and in particular by deoxyribonuclease 1-like 3 (DNASE1L3), can lead to the production of anti-DNA antibodies and SLE [1].