ANKRD44 and systemic lupus erythematosus: For ‘interferon alpha levels in systemic lupus erythematosus’ (5 genes in GWAS), there is one overlap gene, ANKRD44, found to function as a negative regulator in the type I IFN signaling pathway, with decreased expression of ANKRD44 constituting one of the mechanisms for the dysregulated IFN response in SLE [44].