In accordance with these results, previous studies have demonstrated that Hoxd9 regulates the expression of several genes involved in neuronal apoptosis, displaying increased expression in unfavorable brain tumors, whereas its loss of function causes defects in axonal targeting and reduction in neural cell numbers, suggesting its utility as a potential therapeutic target at the crossroads between neurodegeneration and cancer [111,113,114,115]. Here, HOXD9 is linked to brain neoplasm.