Notably, a marked decrease of Nr4a1 was associated with a variety of neurological conditions, including Alzheimer’s and Parkinson’s diseases, and its pharmacological activation exerts neuroprotective, anti-inflammatory and pro-survival effects, proposing Nr4a1 as a potential therapeutic target for multiple neurological disorders [120,122,123,125,126,127,128,129,130,131,132,133,134]. This evidence concerns the gene NR4A1 and Parkinson disease.