CBS and neoplasm: In gastric cancer cells under the 1% O2 hypoxia condition, HIF-1α transactivates the long noncoding RNA CBSLR, which in turn forms a complex with YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) and CBS mRNA to reduce CBS mRNA stability in an N6-methyladenosine (m6A) modification-dependent manner, thus reducing the ACSL4 methylation, degrading ACSL4 via the ubiquitination-proteasome pathway, and eventually protecting gastric cancer cells from ferroptosis in a hypoxic tumor microenvironment [104].