CHAC1 and glioblastoma: In glioblastoma (GBM), HIF-2α induced by the prolyl hydroxylase (PHD) inhibitor roxadustat, upregulated ferroptosis regulatory genes such as ACSL4, PTGS2, and CHAC1, to enhance lipid peroxidation and erastin-induced ferroptosis, leading to the suppression of GBM cell growth in vitro and in vivo [118].