In non-small cell lung cancers, 1% O2 hypoxia induces the intracellular expression of angiopoietin-like 4 (ANGPTL4) and its extracellular secretion by exosomes to neighboring normoxic cells, both of which increase the expression of GPX4, SLC7A11, FTL, and FTH1, to inhibit the RSL3- or irradiation-induced ferroptosis [111]. Here, ANGPTL4 is linked to non-small cell lung carcinoma.