A recent study on clear cell renal cell carcinoma showed that the iron sulfur cluster assembly 2 (ISCA2), a component of the late mitochondrial iron sulfur cluster assembly complex, was induced by hypoxia (1% O2) to promote HIF-1α/HIF-2α translation, leading to the inhibition of iron overload and erastin- or RSL3-induced ferroptosis [102]. Here, EPAS1 is linked to clear cell renal carcinoma.