Previous reports have shown that in CAFs derived from pancreatic ductal adenocarcinoma less than 10% of the population express MSC markers CD90, CD49a, CD44 and CD73; furthermore, it was also observed that CAFs, unlike MSCs, possess low differentiation capacity towards adipocytes, chondrocytes and osteocytes [41]. Here, NT5E is linked to pancreatic ductal adenocarcinoma.