In addition to this, analysis of top 100 genes that are differentially regulated in PLA2G2A+ IPF fibroblasts has shown upregulation of multiple key extra cellular matrix (ECM) genes such FBLN1, COL1A2, COL1A1, MFAP5, FBN1, COL3A1, COL6A1, COL6A2 and COL14A1 (Figure 2G). Here, COL1A2 is linked to idiopathic pulmonary fibrosis.