For example, squamous non-small cell lung cancer cells (CRL-5889) exposed to s-μg using an RPM for 72 h showed increased spheroidal apoptosis and upregulation of TP53, CDKN2A, PTEN, SOX2, and RB1, while the expression of AKT3, PIK3CA, and NFE2L2 remained unchanged (Figure 5) [196]. The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.