Remarkably, genes related to osteoarthritis (BMP8A, CD36, COL10A1, COL9A3, FGF1, IBSP, IHH, MMP10, PHOSPHO1, S100A1, and SPP1) were significantly upregulated only in the female high-responder group, but not in the two others [151]. This evidence concerns the gene SPP1 and osteoarthritis.