BRCA1 and adenocarcinoma: Investigating the adenocarcinoma cell line (CRL2351), Strube et al. observed an upregulation of BRCA1, RHOA, VIM, HER2, and MAPK1 in all cells cultured under s-μg (adherent and spheroids), whereas ERBB2 was upregulated in the spheroids, but not in the adherent cells after a five-day RPM exposure.