SGCB and melanoma: Ivanova et al. [202] studied the impact of clinorotation using a fast-rotating 2D clinostat on the gene expression of NOS isoforms, sGC, GC-A/GC-B, and multidrug resistance-associated proteins 4/5 (MRP4/MRP5) as selective cGMP exporters in human metastatic melanoma cells (highly metastatic and non-pigmented BLM melanoma cells) (Table 9).