As for the anxiety-like behaviors, at 21 days after mTBI, the mice did not prefer open arms, but preferred to stay in closed arms, where they felt safer and more isolated, releasing their emotional and physiological manifestations of depression, while inhibition of LRRK2 kinase activity by 14 days of treatment with the antagonist PF-475 facilitates exploration of the open arm of the EPM test and alters the tendency in the mice to react rather than remain at rest. This evidence concerns the gene LRRK2 and major depressive disorder.