Multivariable analysis confirmed that thrombocytopenia (HR = 3.07), high LDH level (HR = 2.59), presence of del17p/TP53 (HR = 2.25), presence of t(11;14) IGH/CCND1 (a trend toward significance; HR = 2.34) and the TT genotype of the KIAA1524 gene (rs2278911) (HR = 7.57) were independent prognostic factors for a higher risk of progression. This evidence concerns the gene CIP2A and Thrombocytopenia.