A high CIP2A concentration has been found to serve as a negative prognostic factor in a number of human cancers [35], and CIP2A knockdown has been shown to inhibit the activity of MYC, E2F1 and Akt [30]; restrict tumor growth in oral cancer mice models [47] and result in decreased proliferation and increased apoptosis of human MM cells [48]. This evidence concerns the gene E2F1 and Miyoshi myopathy.