The univariable analysis identified the following factors as significantly related to higher risk of OS death: light chain disease (HR = 2.37), stage 3 disease according to the ISS classification (stage 3; HR = 2.03), higher stage of chronic kidney disease (>G2: HR = 1.78), poor performance status (PS: 2–4; HR = 2.01), the presence of anemia before treatment (HR = 2.43), low albumin levels (HR = 2.28), high B2M levels (HR = 2.73), high creatinine levels (HR = 1.74), the presence of del17p/TP53 (HR = 1.84) and the presence of t(11;14) IGH/CCND1 (HR = 2.62). This evidence concerns the gene B2M and chronic kidney disease.