In the present study, we aimed to investigate the association between CAV1 and proinflammatory cytokines in the AT from normoglycemic lean and obese individuals, to determine the independent predictors that may influence CAV1 gene regulation, and to further elucidate the role of CAV1 in obesity and the regulatory mechanism involved. This evidence concerns the gene CAV1 and obesity due to melanocortin 4 receptor deficiency.