In compliance with data obtained for thyroid cancer cells [45] and lung adenocarcinoma cells [74], our results on the A431 squamous cell carcinoma cells treated with Octa or A02 indicate the reversion of the TGF-β1-induced EMT markers and the inhibition of cell migration in association with the downregulation of p38 MAPK, AKT, and ERK phosphorylation. The gene discussed is AKT1; the disease is thyroid cancer.