In compliance with data obtained for thyroid cancer cells [45] and lung adenocarcinoma cells [74], our results on the A431 squamous cell carcinoma cells treated with Octa or A02 indicate the reversion of the TGF-β1-induced EMT markers and the inhibition of cell migration in association with the downregulation of p38 MAPK, AKT, and ERK phosphorylation. This evidence concerns the gene AKT1 and squamous cell carcinoma.