NeuN immunohistological staining of neurons in the cortex revealed that while there was a significantly lower neuronal count (higher neuronal loss) in the AD mice than in the non-AD mice, the mitochondria-treated AD mice had a higher neuronal count than untreated AD mice, as follows: one-way ANOVA showed a significant difference between the groups [f(2, 12) = 12.59, p = 0.001]. This evidence concerns the gene RBFOX3 and Alzheimer disease.