When analyzing the altered proteins by comparing separately the AD vs. non-AD mice, the AD vs. treated AD mice, and the treated AD vs. non-AD mice, we identified Treatment Rescued proteins, such as R3hcc1, Pik3r1 and Gstp3, and Treatment Effect proteins (without a Tg effect), such as Igfbp2 and Glb1 (Table S1 and Supplemental-liver-proteomics-excel). The gene discussed is IGFBP2; the disease is Alzheimer disease.