The role of the CCR2 chemokine receptor. CCR2 is induced on the neutrophil surface during sepsis in a TLR2/4 dependent manner; this promiscuous chemokine receptor is probably not involved in neutrophil recruitment to the infectious site [223], but it seems to be involved in neutrophil recruitment to vital organs and the pathogenesis of organ failure [223,224]. This evidence concerns the gene CCR2 and Sepsis.