CD274 and Sepsis: Furthermore, studies in human inflammatory diseases suggest that the neutrophil heterogeneity is even more extensive, including CD63+ or PD-L1+ subsets identified in patients with cystic fibrosis [293,294], CD64+ neutrophils as a marker of sepsis (see below) [270], subsets expressing the receptor activator of nuclear factor κB ligand (RANKL) identified in chronic obstructive pulmonary disease [295], CD49d+ neutrophils detected in the nasal fluid during viral infections [296], and HLA-DR+ subsets in patients with Leishmaniosis [297].