CXCR2 and Sepsis: Hydrogensulfide-synthesis and its influence on endothelial adhesion. The activity of the hydrogen sulfide-synthesizing enzyme cystathionine g-lyase is increased in sepsis; its increased activity seems to be associated with increased neutrophil adhesion to endothelium, increased migration/chemotaxis, and maintained/increased CXCR2 expression in murine sepsis [229,230].