A study conducted by Behrens, C. et al., showed how bFGF/FGFR1-2 signaling plays an important role in the pathogenesis of squamous carcinoma cells and adenocarcinoma; the study considers the immunohistochemical expression of the three molecules in 426 epithelial samples containing histologically normal, hyperplastic, squamous metaplastic, or squamous dysplastic bronchial epithelia adjacent to NSCLC obtained from 130 patients [143]. Here, FGF2 is linked to non-small cell lung carcinoma.