FGF2 and hepatocellular carcinoma: Likewise, in the human hepatoma cell line SMMC-7721 and Hep3B, the angiogenesis pathways such as PI3K-Akt, VEGF/KDR, and Angiopoietins/Tie2 and the angiogenic factors such as bFGF [109] were upregulated and consequently suppressed by Plumbagin administration [110].