Confirming this, preclinical assessments have indicated curcumin as a potential natural compound to inhibit 4NQO-induced tumorigenesis via modulation of the bFGF/FGFR-2 axis [131] and AZD4547 as a new chemical molecule targeting the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in HNSCC [132]. Here, FGF2 is linked to head and neck squamous cell carcinoma.