Finally, inhibition of β-catenin in triple negative breast cancer cell lines was shown to impair ribosome biogenesis, and the authors moreover showed that a number of genes encoding ribosome biogenesis factors were predicted to be TCF/LEF targets, including LAS1-like ribosome biogenesis factor (LAS1L), an endonuclease involved in pre-rRNA processing, and Fibrillarin, a methyltransferase that mediates 2′-O-methylation of rRNA [112]. This evidence concerns the gene LAS1L and triple-negative breast carcinoma.