Their effect on the stimulation of an adaptive anti-tumor immune response is manifested by the promotion of (a) the ability of cells to present antigens, (b) the activation of T and B lymphocytes, (c) the increase in the number and activity of natural killer effector cells, and (d) the production of antibodies and active substances, i.e., tumor necrosis factor α (TNF-α) and interleukins (IL-6, IL-8, and IL-12) [56]. The gene discussed is TNF; the disease is neoplasm.