Then, we evaluated changes in mitochondrial parameters (24 h) in human iPSC-derived astrocytes (expressing the biosensor MitoTimer) treated with BDF-LEVs isolated from a pool of patients diagnosed with 3R-tau (PiD) or 4R-tau (PSP) tauopathy, and non-demented control subjects (C) (Figure 5A and Figure S2A). This evidence concerns the gene MAPT and tauopathy.