Circulating proteins with high concentrations, such as TGF-β, TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-10, MCP-1, MIP-1β, Eotaxin, and IL-1, were identified in human cases of CM [81,105]. The gene discussed is CXCL8; the disease is cutaneous mastocytosis.