Pathways closely related to endocrine aging were extracted from the KEGG pathway, including pancreatic cancer, oxytocin signaling pathway, ErbB signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, prolactin signaling pathway, MAPK signaling pathway, thyroid hormone signaling pathway, insulin resistance, endocrine resistance, AMPK signaling pathway. The gene discussed is HIF1A; the disease is pancreatic neoplasm.