The four miRNAs upregulated during FU In PCOS patients (Table 2), pathways such as initial and antibody triggering of complement, activation of C4 and C2, B-cell receptor regulation, and antimicrobial peptides are depleted for mRNA targets of the upregulated miRNAs, possibly suggesting a relatively lower impact of the upregulated miRNAs. The gene discussed is C4A; the disease is polycystic ovary syndrome.