The women with PCOS changed clinically during the 6-yr FU towards a more impaired metabolic (in terms of increasing BMI, insulin levels, HOMA-IR, and levels of C-peptide) and less hyperandrogenic (in terms of decreasing DHEAS, SHBG, total T, free T, and androstenedione). Here, SULT2A1 is linked to polycystic ovary syndrome.