For instance, it has been shown that an increase in meningeal lymphangiogenesis through injection of adeno-associated virus 8-vascular endothelial growth factor C (AAV8-VEGF-C) into the cisterna magna of bile duct ligation-induced rats with HE reduced microglial activation, improved the glymphatic function, decreased the expression of proinflammatory cytokines in the cerebral cortex, and improved the motor function [46]. The gene discussed is VEGFC; the disease is hereditary elliptocytosis.