THBD and acute respiratory distress syndrome: In the CITRIS-ALI randomized clinical trial it was found that a 96-h infusion of vitamin C (50 mg/kg in dextrose 5% in water every 6 h for 96 h) could not modify levels of CRP, thrombomodulin, and modified Sequential Organ Failure Assessment (mSOFA) scores in patients with sepsis and severe acute respiratory distress syndrome.