The ACE2-mediated direct viral invasion of the hepatocytes, disrupted immune homeostasis, systemic inflammatory response, concomitant hypotension, pneumonia-associated hypoxia, cytokine storm with increased proinflammatory cytokines, and drug use suggest a pathogenesis of liver injury in patients with long-term COVID-19 [27,28]. The gene discussed is ACE2; the disease is COVID-19.