ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Weight loss was expected to lead to an increase in salivary adiponectin levels, as BMI levels show reduced obesity, which is correlated with higher adiponectin levels [32] and plasma levels of HMW adiponectin have been reported to increase in 40 ± 15% in 1 month and in 58 ± 8% at 12 months after gastric bypass surgery in one study [33] and from 11.4 ± 0.7 mg/L before surgery to 15.7 ± 0.7 and 19.8 ± 1.0 at 6 and 12 months after surgery, respectively [34].