Thus, cerebrovascular pathology appears a mechanistic link between TBI and AD since neurovascular injuries can accelerate Aβ synthesis and accumulation on the artery wall, while arterial stiffness, α-syn protein misfolding, persistent inflammation, tau hyperphosphorylation, and tau/Aβ-induced BBB damage concur in post-concussive syndrome and dementia (recently reviewed in [15,105]). The gene discussed is MAPT; the disease is post-concussion syndrome.