Among the mRNA targets identified, more of them were described as key regulators of sperm motility as: (i) the reduction of CYP19, both transcript and enzymatic activity, has been correlated with sperm motility reduction [40]; (ii) lysophosphatidic acid (LPA) via LPA receptors (LPAR) improves sperm motility by enhancing the glycolysis pathway [41]; (iii) CHD7 gene missense variants occur in the azoospermia condition [42]; (iiii) PLAG1 deficiency negatively affects sperm motility in mice [43]; voltage-gated sodium channels NAV were identified in bull SPZ [44]. Here, PLAG1 is linked to Azoospermia.