PKM and cancer: CircADAM10—through mmu-miR-670-3p, mmu-miR-509-5p, mmu-miR-1903, mmu-miR-5106, and mmu-miR-7220-3p—controls the expression of several targets as (i) FAS-ligand, involved in enterocyte apoptosis following exposure to oxidative stress [53]; (ii) pyruvate kinase M2 isoform (PKM2), essential for ROS adaptation of cancer cells [54]; and (iii) nitric oxide synthase 3 (NOS3), implicated in testicular oxidative stress and oligoasthenozoospermia [55].