Based on the evidence that the C-X-C chemokine receptor 4 (CXCR4) is overexpressed in metastatic esophageal squamous cell carcinoma (ESCC), a study conducted by Peng et al. (2021) [27] produced a probe for the imaging of such systems. This evidence concerns the gene CXCR4 and esophageal squamous cell carcinoma.