We first evaluated the expression and DNA methylation levels of HOXA10, PAX6, ESR1, ESR2, IGFBP1, GAB1, SLC2A4, and IRS1 genes, as well as global DNA methylation levels in the endometrium of PCOS patients and women without the disease (control group). This evidence concerns the gene SLC2A4 and polycystic ovary syndrome.