In addition, POLD1 knockdown in ccRCC cells significantly decreased the levels of autophagy and ferroptosis signaling pathway-related genes, including p62, NRF2, Keap1 and GPX4, which were reported to serve as the vital regulatory factors in many types of cancers [59,60,61]. The gene discussed is GPX4; the disease is nonpapillary renal cell carcinoma.