Most inflammatory biomarkers are equally increased in both PRE-CeD and CeD groups; nevertheless, 94% of PRE-CeD children are correctly differentiated from those with full-blown CeD by a model that includes INFγ and TGFβ gene expression together with TNFα and IL1β serum cytokines. The gene discussed is IL1B; the disease is cranioectodermal dysplasia.