PDPN and Cerebral ischemia: However, it should be noted that although all the loci originated from the genes correlated with cerebral ischemia–reperfusion injury, only three of them (SNPs in genes GPNMB, LSP1, and TAGLN) were associated with outcomes after IS, while one locus (SNP rs1261025 in the PDPN gene) demonstrated associations with IS itself.