This pathway is also involved in the placental changes seen in preeclampsia, miscarriage, and gestational diabetes [24,25,26,27,28,29], and it involves activation of the intracellular innate immunity receptor NLRP3, with subsequent production of Caspase 1, IL-1β, and IL-18 [19,20,21]. This evidence concerns the gene CASP1 and preeclampsia.